期刊
TRENDS IN CELL BIOLOGY
卷 30, 期 11, 页码 869-880出版社
CELL PRESS
DOI: 10.1016/j.tcb.2020.09.003
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资金
- CAS Strategic Priority Research Program [XDA16020602]
- National Key R&D Program of China [2019YFA0110300]
- National Natural Science Foundation of China [81825006, 31730033, 31621004]
- K.C. Wong Education Foundation
During embryonic brain development, neurogenesis requires the orchestration of gene expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with specific emphasis on the modes of histone variants and histone post-translational modifications are involved in interactive gene regulation of central nervous system (CNS) development. Here, we provide a broad overview of the regulatory system of histone variants and histone modifications that have been linked to neurogenesis and diseases. We also review the crosstalk between different histone modifications and discuss how the 3D genome affects cell fate dynamics during brain development. Understanding the mechanisms of epigenetic regulation in neurogenesis has shifted the paradigm from single gene regulation to synergistic interactions to ensure healthy embryonic neurogenesis.
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