期刊
ORGANIC LETTERS
卷 22, 期 21, 页码 8215-8218出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02645
关键词
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资金
- National Natural Science Foundation of China [81991525, 21861142006, 81872793, 81630089]
- National Research Development and Innovation Office [K-120181]
- EU
- European Regional Development Fund [GINOP-2.3.2-15-2016-00008]
- COMRA [DY135-B-05]
- [2018ZX09711001-001-008]
LC-MS-oriented fractionation of the sponge Aaptos suberitoides resulted in the isolation of four heptacyclic alkaloids, aaptodines A-D (1-4), which contain 9,10-dihydrofuro[2,3-f][1,3]oxazolo[5,4-h]-quinolone and 7,8-dihydrocyclopenta[de][1,6]naphthyridine subunits with a spiro carbon atom. The structures were determined on the basis of NMR spectroscopic and single-crystal X-ray diffraction data analysis aided by electronic circular dichroism calculations and Mosher's method. A biosynthetic pathway for the formation of aaptodines A-D is postulated. Aaptodine D exhibits potent inhibition against osteoclast formation.
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