期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 86, 页码 13129-13132出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04803h
关键词
-
资金
- National Institutes of Health [AG048934]
In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-beta (1-40) in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.
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