期刊
ADIPOCYTE
卷 9, 期 1, 页码 649-652出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21623945.2020.1838186
关键词
GPR120; PPAR gamma; type 2 diabetes; insulin resistance; metabolism
资金
- NIH [R01 DK108773]
- American Heart Association [14SDG19880020]
- American Diabetes Association Minority Postdoctoral Fellowship [1-18-PMF -030]
G Protein-coupled receptor 120 (GPR120; fatty acid receptor 4, FFAR4) and PPAR gamma agonists both lead to anti-inflammatory and insulin sensitizing effects despite signalling through distinct pathways. We recently reported the overarching idea that these two pathways are interactive. Specifically, treatment of obese mice with the PPAR gamma agonist rosiglitazone (a thiazolidinedione, TZD) in combination with the GPR120 agonist compound A synergistically improves glucose tolerance and insulin sensitivity. We have deconvoluted the mechanisms underlying this feed-forward effect in the study. Taken together, our study shows that low dose TZD administration, in combination with GPR120 agonists, produces additive beneficial effects on glucose tolerance and insulin sensitivity without the undesirable adverse effects of TZD. Our study suggests potential value of combination PPAR gamma and GPR120 agonists to treat metabolic disease.
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