Hepatocellular Carcinoma Role of Pathology in the Era of Precision Medicine

Comprehensive molecular profiling of HCC has ushered a new era in the pathology of hepatocellular neoplasms. morpho-molecular correlation studies have enabled identification of histologic features associated with specific molecular alterations. The role of pathology has shifted from mere diagnosis to prediction of prognosis and response to targeted therapy. In addition to guiding the surgeon's hand, pathology is now also guiding oncologists in treating patients in this era of precision medicine. The role of pathology will continue to evolve as we learn more about the complex underpinnings and continue to find more morphologic correlates of molecular alterations of HCC to offer better personalized to patients.