期刊
SMALL
卷 16, 期 46, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202003496
关键词
bimetallic oxide FeWO; (X) nanosheets; multimodal imaging; nanozymes; oxygen vacancies; photoacoustic imaging
类别
资金
- National Basic Research Programs of China (973 Program) [2016YFA0201200]
- National Natural Science Foundation of China [51525203, 51761145041, 51572180, 91959104]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Jiangsu Natural Science Fund for Distinguished Young Scholars [BK20170063]
- Project Funded for Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_2656]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
- Innovation Fund of WNLO [2018WNLOKF024]
- State Key Laboratory of Radiation Medicine and Protection [GZK1201810]
Nanozymes with high catalytic activity and great stability have attracted increasing interests as the promising alternative to natural enzymes for applications in various fields. In this study, a new type of highly efficient peroxidase-like nanozymes based on FeWOX nanosheets (NSs) synthesized by a thermal-decomposition method is reported. Owing to the sheet-structure with maximized utilization of catalytic sites (Fe atoms and oxygen vacancies), such FeWOX NSs exert efficient enzyme activity to trigger catalytic decomposition of hydrogen peroxide (H2O2) into hydroxyl radicals (center dot OH). A nanozyme-based ratio-metric nanoprobe is then fabricated by co-loading of 3,3,5,5-tetramethylbenzidine (TMB) and IR780 dye on FeWOX NSs to enable ratio-metric photoacoustic (PA) imaging of endogenous H2O2, as verified by imaging of the subcutaneous 4T1 xenograft tumor model and lipopolysaccharide (LPS)-induced inflammation model. Moreover, FeWOX NSs could also be employed as promising nanoagents for multimodal computed tomography (CT) and magnetic resonance (MR) imaging of tumors, due to the strong X-ray attenuation ability of W element and high MR contrast ability of Fe element, respectively. Importantly, FeWOX NSs with good biodegradability could be cleared out from the body without any significant biotoxicity. This work highlights bimetallic oxide FeWOX NSs as an enzyme-mimetic nanoplatform for imaging of the tumor microenvironment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据