期刊
DRUG DELIVERY
卷 27, 期 1, 页码 1438-1451出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10717544.2020.1831104
关键词
Growth factors; biomaterials; delivery strategies
资金
- Key Research and Discovery Program of Shandong Province [2019GSF107072]
- High-Level Talent Research Foundation of Qingdao Agricultural University, China [1119007]
- National Natural Science Foundation of China [NSFC 31802229]
Growth factors are multi-functional signaling molecules that coordinate multi-stage process of wound healing. During wound healing, growth factors are transmitted to wound environment in a positive and physiologically related way, therefore, there is a broad prospect for studying the mediated healing process through growth factors. However, growth factors (GFs) themselves have disadvantages of instability, short life, rapid inactivation of physiological conditions, low safety and easy degradation, which hinder the clinical use of GFs. Rapid development of delivery strategies for GFs has been trying to solve the instability and insecurity of GFs. Particularly, in recent years, GFs delivered by scaffolds based on biomaterials have become a hotspot in this filed. This review introduces various delivery strategies for growth factors based on new biodegradable materials, especially polysaccharides, which could provide guidance for the development of the delivery strategies for growth factors in clinic.
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