期刊
CELL
卷 183, 期 4, 页码 860-874出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.10.027
关键词
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资金
- Collectif Ensemble contre le Melanome, Melanoma Research Alliance [565840]
- Rising Tide Foundation for Clinical Cancer Research [CCR-18-100]
- Sebastien Bazin
- Fondation Carrefour
Persistent cancer cells are the discrete and usually undetected cells that survive cancer drug treatment and constitute a major cause of treatment failure. These cells are characterized by their slow proliferation, highly flexible energy consumption, adaptation to their microenvironment, and phenotypic plasticity. Mechanisms that underlie their persistence offer highly coveted and sought-after therapeutic targets, and include diverse epigenetic, transcriptional, and translational regulatory processes, as well as complex cell-cell interactions. Although the successful clinical targeting of persistent cancer cells remains to be realized, immense progress has been made in understanding their persistence, yielding promising preclinical results.
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