期刊
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40164-020-00187-x
关键词
T-cell acute lymphoblastic leukemia; NOTCH1; γ -Secretase inhibitors; SERCA inhibitors; Monoclonal antibody
资金
- National Natural Science Foundation of China [81800137]
T-cell acute lymphoblastic leukemia (T-ALL) is one of the hematological malignancies. With the applications of chemotherapy regimens and allogeneic hematopoietic stem cell transplantation, the cure rate of T-ALL has been significantly improved. However, patients with relapsed and refractory T-ALL still lack effective treatment options. Gene mutations play an important role in T-ALL. The NOTCH1 gene mutation is the important one among these genetic mutations. Since the mutation of NOTCH1 gene is considered as a driving oncogene in T-ALL, targeting the NOTCH1 signaling patheway may be an effective option to overcome relapsed and refractory T-ALL. This review mainly summarizes the recent research advances of targeting on NOTCH1 signaling pathway in T-ALL.
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