期刊
NEUROIMAGE
卷 222, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.117299
关键词
-
资金
- British Academy Postdoctoral fellowship
- Autism Research Trust
- Fonds de la Recherche du Quebec - Sante(FRQS)
- National Science and Engineering Research Council of Canada (NSERC) [1304413]
- Canadian Institutes of Health Research (CIHR) [FDN-154298]
- Azrieli Center for Autism Research of the Montreal Neurological Institute (ACAR)
- SickKids Foundation [NI17-039]
- Canada Research Chairs Program
- British Academy Postdoctoral Fellowship [PF160048]
- Guarantors of Brain [G101149]
- Biotechnology and Biological Sciences Research Council [BB/H008217/1]
- MRC research infrastructure award [MR/M009041/1]
- NIHR Cambridge Biomedical Research Centre
- CambridgeMNI collaborative research grant
- BBSRC [BB/H008217/1] Funding Source: UKRI
- MRC [MR/M009041/1] Funding Source: UKRI
Ageing is commonly associated with changes to segregation and integration of functional brain networks, but, in isolation, current network-based approaches struggle to elucidate changes across the many axes of functional organisation. However, the advent of gradient mapping techniques in neuroimaging provides a new means of studying functional organisation in a multi-dimensional connectivity space. Here, we studied ageing and behaviourally-relevant differences in a three-dimensional connectivity space using the Cambridge Centre for Ageing Neuroscience cohort (n = 643). Building on gradient mapping techniques, we developed a set of measures to quantify the dispersion within and between functional communities. We detected a strong shift of the visual network across the adult lifespan from an extreme to a more central position in the 3D gradient space. In contrast, the dispersion distance between transmodal communities (dorsal attention, ventral attention, frontoparietal and default mode) did not change. However, these communities themselves were increasingly dispersed with increasing age, reflecting more dissimilar functional connectivity profiles within each community. Increasing dispersion of frontoparietal, attention and default mode networks, in particular, were associated negatively with cognition, measured by fluid intelligence. By using a technique that explicitly captures the ordering of functional systems in a multi-dimensional hierarchical framework, we identified behaviorally-relevant age-related differences of within and between network organisation. We propose that the study of functional gradients across the adult lifespan could provide insights that may facilitate the development of new strategies to maintain cognitive ability across the lifespan in health and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据