期刊
SMALL
卷 16, 期 46, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202001343
关键词
Ce6; Fe– Mn layered double hydroxides; Fenton‐ like reaction; phototherapy; upconversion nanoparticles
类别
资金
- National Natural Science Foundation of China [NSFC 51772059, 51720105015, 51602072]
- Chinese Government [2017YFE0132300]
- Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund [21728101]
- CAS-Croucher Funding Scheme for Joint Laboratories [CAS18204]
- Natural Science Foundation of Heilongjiang Province [QC2016009]
- Fundamental Research funds for the Central Universities
- Australian Government [2017YFE0132300]
Multimodal synergistic therapy based on photodynamic therapy (PDT), photothermal therapy (PTT), and chemodynamic therapy (CDT) has attracted increasing attention in cancer therapy. However, the scant therapeutic efficiency is always a barrier for further application. Herein, a smart tumor microenvironment (TME) responsive nanocatalysts are developed by adopting Fe-Mn layered double hydroxides (FeMn-LDH) as an effective photothermal nanocarrier to load mesoporous silica and chlorin e6 (Ce6)-covalently coated upconversion nanoparticles (UCSP) for multimodal imaging for directed therapy. Under acidic TME, FeMn-LDH degrades into Fe3+ and Mn2+ ions to initiate a Fenton-like reaction inducing CDT and enhancing magnetic resonance imaging. Additionally, Fe3+ can decompose H2O2 to oxygen (O-2), enhancing PDT guided by UCSP. As a representative noninvasive imaging probe, the upconversion luminescence will recover after decomposition of FeMn-LDH, and provide high-resolution upconversion luminescent imaging guidance for pinpointed PDT. Moreover, the photothermal properties of FeMn-LDH can further enhance CDT effects. The synergistic therapy and multifunctional imaging can realize the integration of diagnosis and treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据