期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 15, 期 23, 页码 4033-4037出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202001105
关键词
DNA-encoded chemical library; Diversity-oriented synthesis; Aldol reaction; Heterocycle; C(sp(3))− C(sp(3)) bond formation; C(sp(3))− C(sp(2)) bond formation
A DNA-encoded chemical library (DECL) is built with combinatorial chemistry, which works by bringing chemical fragments together to generate diverse structures. However, chemical diversity of DNA-encoded chemical libraries is often limited by DNA compatible synthetic reactions. This report shows a conceptual strategy to expand chemical space of DNA-encoded chemical libraries by incorporation of diversity-oriented synthesis in DECL synthesis. We developed Aldol reactions on DNA in a combinatorial way. After obtaining DNA-tagged alpha, beta-unsaturated ketones which represent important chemical intermediates, many distinct structures with skeletal diversities are achieved by diversity-oriented synthesis.
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