期刊
ORGANIC CHEMISTRY FRONTIERS
卷 7, 期 21, 页码 3515-3520出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo01092h
关键词
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资金
- National Natural Science Foundation of China [22001188]
- Natural Science Foundation of Zhejiang Province [LQ19B020001]
- Project of Taizhou University Fund for Excellent Young Scholars
- Science and Technology Plan Project of Taizhou [1803gy04]
The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation. Here, we present a combined KOtBu/BEt3 catalyst for the deoxygenative reduction of tertiary, secondary, and even notoriously challenging primary carboxamides with pinacolborane (HBpin) at 25-60 degrees C. This novel transition-metal-free methodology is readily applicable to the synthesis of drug molecules.
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