期刊
CHEMICAL SCIENCE
卷 11, 期 41, 页码 11189-11194出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc04032k
关键词
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资金
- Swedish Research Council (VR)
- Stiftelsen Olle Engkvist Byggmastare
- Knut and Alice Wallenberg Foundation [KAW 2018:0066]
We have developed a simple protocol for the preparation of 1,2-fluorohydrin by asymmetric hydrogenation of fluorinated allylic alcohols using an efficient azabicyclo thiazole-phosphine iridium complex. The iridium-catalyzed asymmetric synthesis of chiral 1,2-fluorohydrin molecules was carried out at ambient temperature with operational simplicity, and scalability. This method was compatible with various aromatic, aliphatic, and heterocyclic fluorinated compounds as well as a variety of polyfluorinated compounds, providing the corresponding products in excellent yields and enantioselectivities.
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