期刊
ORGANIC CHEMISTRY FRONTIERS
卷 7, 期 21, 页码 3446-3451出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo00888e
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资金
- National Natural Science Foundation of China [21502043, 21871128]
- Special Funds of the Taishan Scholar Program of Shandong Province [tsqn201812047]
- Natural Science Foundation of Shandong Province [ZR2017JL011]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]
- Guangdong Provincial Key Laboratory of Catalysis [2020B121201002]
A chiral phosphoric acid catalyzed site-selective 1,6-conjugate addition of N-aryl-3-oxobutanamides to in situ formed propargylic aza-p-quinone methides from propargylic alcohols has been established and this represents the first report on organocatalytic site- and stereoselective 1,6-conjugate addition of propargylic aza-para-quinone methides. Furthermore, the synthetic strategy enables the formation of diarylmethyl alkynes bearing vicinal quaternary and tertiary carbon stereocenters in high yields with high asymmetric induction.
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