期刊
EXPERIMENTAL CELL RESEARCH
卷 396, 期 1, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2020.112246
关键词
Heat shock factor 1; Hsp70; Hsp90; Protein homeostasis; Misfolded proteins; Heat shock response
资金
- Swedish Cancer Society [CAN2018/711]
- Swedish Research Council [2019-04052]
- Knut and Alice Wallenberg Foundation
- Swedish Research Council [2019-04052] Funding Source: Swedish Research Council
Heat shock factor 1 (Hsf1) is an ancient transcription factor that monitors protein homeostasis (proteostasis) and counteracts disturbances by triggering a transcriptional programme known as the heat shock response (HSR). The HSR is transiently activated and upregulates the expression of core proteostasis genes, including chaperones. Dysregulation of Hsf1 and its target genes are associated with disease; cancer cells rely on a constitutively active Hsf1 to promote rapid growth and malignancy, whereas Hsf1 hypoactivation in neurodegenerative disorders results in formation of toxic aggregates. These central but opposing roles highlight the importance of understanding the underlying molecular mechanisms that control Hsf1 activity. According to current understanding, Hsf1 is maintained latent by chaperone interactions but proteostasis perturbations titrate chaperone availability as a result of chaperone sequestration by misfolded proteins. Liberated and activated Hsf1 triggers a negative feedback loop by inducing the expression of key chaperones. Until recently, Hsp90 has been highlighted as the central negative regulator of Hsf1 activity. In this review, we focus on recent advances regarding how the Hsp70 chaperone controls Hsf1 activity and in addition summarise several additional layers of activity control.
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