期刊
GREEN CHEMISTRY
卷 22, 期 20, 页码 6792-6797出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0gc02618b
关键词
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资金
- Spanish Government [RTI2018-095038-B-I00]
- ERC (ERC-CG) [647550]
- Comunidad Autonoma de Madrid [PEJD-2018POST/AMB-8938, PEJD-2018-POST/AMB-8938, 2017-T2/AMB-5037]
- Comunidad de Madrid [S2018/NMT-4367]
- European Structural Funds [S2018/NMT-4367]
A sustainable synthesis of isothiazoles has been developed using an alpha-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method is highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup.
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