期刊
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
卷 27, 期 11, 页码 3018-3024出版社
ELSEVIER
DOI: 10.1016/j.sjbs.2020.08.029
关键词
Avicennia marina; Silver nanoparticle; Anti-cancer activity; Cytotoxicity assay; ROS generation; Mitochondrial damage
类别
资金
- King Saud University, Riyadh, Saudi Arabia [RSP-2020/119]
The biosynthesized Ag NPs was synthesized by using marine mangrove plant extract Avicennia marina. The synthesized Ag NPs was confirmed by various physiochemical characterization including UV-spectrometer and XRD analysis. In addition, the shape and of the synthesized Ag NPs was morphologically identified by SEM initially and TEM finally. After confirmation, the anti-cancer property of synthesized Ag NPs was confirmed at 50 mu g/mL concentration against A549 lung cancer cells by MIT assay. Further, the ability to stimulate the ROS generation and mitochondrial membrane at the IC50 concentration of Ag NPs was confirmed by fluorescence microscopy using DCFH-DA and rhodamine 123 dyes respectively. Finally, the result was concluded that the synthesized Ag NPs has improved anti-cancer activity against A549 cells at lowest concentration. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
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