期刊
CELL
卷 183, 期 5, 页码 1249-+出版社
CELL PRESS
DOI: 10.1016/j.cell.2020.10.024
关键词
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资金
- EPSRC
- MRC
- Wellcome Senior Research Fellowship [104765/Z/14/Z, 212281/z/18/z]
- Wellcome Principal Research Fellowship [219525/Z/19/Z, 202805/Z/16/Z]
- JS McDonnell Foundation [JSMF220020372]
- Wellcome Collaborator award [214314/Z/18/Z]
- ERC Advanced Grant NEUROMEM
- Wellcome Trust [203139/Z/16/Z, 203147/Z/16/Z]
- Wellcome Trust [212281/Z/18/Z, 219525/Z/19/Z, 214314/Z/18/Z] Funding Source: Wellcome Trust
The hippocampal-entorhinal system is important for spatial and relational memory tasks. We formally link these domains, provide a mechanistic understanding of the hippocampal role in generalization, and offer unifying principles underlying many entorhinal and hippocampal cell types. We propose medial entorhinal cells form a basis describing structural knowledge, and hippocampal cells link this basis with sensory representations. Adopting these principles, we introduce the Tolman-Eichenbaum machine (TEM). After learning, TEM entorhinal cells display diverse properties resembling apparently bespoke spatial responses, such as grid, band, border, and object-vector cells. TEM hippocampal cells include place and landmark cells that remap between environments. Crucially, TEM also aligns with empirically recorded representations in complex non-spatial tasks, TEM also generates predictions that hippocampal remapping is not random as previously believed; rather, structural knowledge is preserved across environments, We confirm this structural transfer over remapping in simultaneously recorded place and grid cells.
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