期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms21218298
关键词
active pharmaceutical ingredients; drug delivery systems; formulations; ionic liquids; solubility; permeability
资金
- FCT/MEC [UIDB/50011/2020, UIDP/50011/2020]
- FEDER under the PT2020 Partnership Agreement
- project IonCytDevice - FEDER, through COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI) [POCI-01-0145-FEDER-031106, PTCD/BTA-BTA/31106/2017]
- national funds (OE), through FCT/MCTE
- [SFRH/BD/132584/2017]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/132584/2017] Funding Source: FCT
Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.
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