期刊
JOURNAL OF PAIN
卷 21, 期 7-8, 页码 751-762出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.pain.2019.11.015
关键词
Opioid; morphine; analgesia; tolerance; microbiome; dysbiosis; dorsal root ganglia
资金
- National Institutes of Health [F30 DA042542, R01 DA036975, P30 D4033934, T37 DA007077]
It is increasingly recognized that chronic opioid use leads to maladaptive changes in the composition and localization of gut bacteria. Recently, this opioid-induced dysbiosis (OID) has been linked to antinociceptive tolerance development in preclinical models and may therefore identify promising targets for new opioid-sparing strategies. Such developments are critical to curb dose escalations in the clinical setting and combat the ongoing opioid epidemic. In this article, we review the existing literature that pertains to OID, including the current evidence regarding its qualitative nature, influence on antinociceptive tolerance, and future prospects. Perspective: This article reviews the current literature on OID of gut bacteria, including its qualitative nature, influence on antinociceptive tolerance, and future prospects. This work may help identify targets for new opioid-sparing strategies. (C) 2019 by United States Association for the Study of Pain, Inc.
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