期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 42, 页码 9642-9651出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb01146k
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资金
- National Key Research and Development Project of China [2019YFC1604900]
- National Key Research and Development Program of China [2019YFC1606400]
- Scientific Research Start-Up Funding for Nanjing Normal University Introduced Talents [184080H202B231]
Microenvironment-related parameters like viscosity, polarity, and pH play important roles in controlling the physical or chemical behaviors of local molecules, which determine the physical or chemical behaviors of surrounding molecules. In general, changes of the internal microenvironment will usually lead to cellular malfunction or the occurrence of relevant diseases. In the last few decades, the field of chemicobiology has received great attention. Also, remarkable progress has been made in developing viscosity-sensitive fluorescent probes. These probes were particularly efficient for imaging viscosity in biomembranes as well as lighting up specific organelles, such as mitochondria and lysosome. Besides, there are some fluorescent probes that can be used to quantify intracellular viscosity when combined with fluorescence lifetime (FLIM) and ratiometric imaging under water-free conditions. In this review, we summarized the majority of viscosity-sensitive chemosensors that have been reported thus far.
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