期刊
EUROPEAN JOURNAL OF CANCER
卷 140, 期 -, 页码 37-44出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2020.09.010
关键词
Peritoneal carcinomatosis; Gastrointestinal carcinoma; PIPAC; Oxaliplatin
类别
资金
- French government [PHRC-K 2016]
Objective: The objectives were to define the maximum tolerated dose (MTD), safety profile and pharmacokinetics (PKs) of intraperitoneal oxaliplatin delivered by pressurised intraperitoneal aerosol chemotherapy (PIPAC) in patients with advanced peritoneal carcinomatosis from gastrointestinal tract cancers. Methods: PIPAC was applied every 4-6 weeks, for 5 cycles, in a phase I dose-escalation study using a 3 + 3 design. The first dose level was 90 mg/m(2) with planned increases of 50 mg/m2 per level. Platinum concentration was measured in plasma, tissues and intraperitoneal fluid samples. The trial was registered at ClinicalTrials.gov (NCT03294252). Results: Ten patients with 33 PIPAC sessions were included. No dose limiting toxicity (DLT) occurred at 90 mg/m(2) and two at 140 mg/m(2). The MTD was therefore set at 90 mg/m(2). Overall treatment included a median number of three PIPAC sessions (range: 1-5) and secondary complete cytoreductive surgery for two patients. Overall safety showed 67 grade I-II and 11 grade III-IV toxicities, usually haematologic, digestive (nausea/vomiting, abdominal pain), and fatigue. Oxaliplatin concentrations were three- to four-fold higher in tissue in contact with aerosol than in muscle without contact. At 140 mg/m(2), the plasma oxaliplatin concentration was high with Cmax and area under the curve (AUC)(0-48h) of 1035 mu g/l and 9028 mu g h/L, respectively. Conclusions: The MTD of oxaliplatin during PIPAC is 90 mg/m(2). PK data demonstrate a high tumour concentration and a significant systemic absorption. (C) 2020 Elsevier Ltd. All rights reserved.
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