期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms21218102
关键词
tumor microenvironment; stroma; tumor infiltrating lymphocytes; breast cancer
资金
- Italian Association for Cancer Research AIRC [22759]
- Italian Health Ministry [NET-2016-02363853]
Breast cancer evolves thanks to a dense and close interaction with the surrounding tumor microenvironment (TME). Fibroblasts, leukocytes, blood and lymphatic endothelial cells and extracellular matrix are the constituents of this entity, and they synergistically play a pivotal role in all of the stages of breast cancer development, from its onset to its metastatic spread. Moreover, it has been widely demonstrated that variations to the TME can correspond to prognosis variations. Breast cancer not only modulates the transformation of the environment within the mammary gland, but the same process is observed in metastases as well. In this minireview, we describe the features of TME within the primitive breast cancer, throughout its evolution and spread into the main metastatic sites.
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