期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 44, 页码 9035-9038出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01985b
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资金
- National Natural Science Foundation of China [81773602, 41906106]
- Guangdong Provincial Special Fund for Marine Economic Development Project [[2020]042]
- Guangdong Special Support Program [2019TQ05Y375]
- Innovation Promotion Association of CAS [2020342]
- Team Project of the Natural Science Foundation of Guangdong Province [2016A030312014]
A highly substituted phenol derivative, effphenol A (1), was isolated from the deep-sea-derived fungus Trichobotrys effuse FS524. Its complete structural assignment was established through a combination of spectroscopic analysis together with single-crystal X-ray diffraction experiments and further unequivocally confirmed by a biomimetic total synthesis. Structurally, effphenol A possesses a poly-substituted 6-5/6/6 tetracyclic ring system, which represents the first case of such a skeleton found in nature. Furthermore, the cytotoxic activity of effphenol A (1) toward four human cancer cell lines was assayed.
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