期刊
MOLECULES
卷 25, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/molecules25215167
关键词
anticancer; photoactivatable platinum drugs; photoactivate chemotherapy; prodrugs
资金
- Shenzhen Science and Technology Innovation Commission [JCYJ20170412113009742]
- SZU Top Ranking Project [86000000210]
- SZU Medical Young Scientists Program
Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of action, including photoreduction, photo-uncaging, and photodissociation. The rationale of drug design, dark stability, photoactivation process, cytotoxicity, and mechanism of action of typical photoactivatable platinum drugs were reviewed. Finally, the challenges and opportunities for designing more potent photoactivatable platinum drugs were discussed.
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