期刊
CURRENT OPINION IN SYSTEMS BIOLOGY
卷 24, 期 -, 页码 71-77出版社
ELSEVIER
DOI: 10.1016/j.coisb.2020.10.001
关键词
Adaptive immunity; Adaptive immune receptor repertoire (AIRR) community; B-cell and T-cell receptor repertoires; FAIR Principles; Open source
Systems biology involves network-oriented, computational approaches to modeling biological systems through analysis of big biological data. To contribute maximally to scientific prog-ress, big biological data should be FAIR: findable, accessible, interoperable, and reusable. Here, we describe high -throughput sequencing data that characterize the vast diversity of B-and T-cell clones comprising the adaptive immune re-ceptor repertoire (AIRR-seq data) and its contribution to our understanding of COVID-19 (coronavirus disease 19). We describe the accomplishments of the AIRR community, a grass-roots network of interdisciplinary laboratory scientists, bioinformaticians, and policy wonks, in creating and publishing standards, software and repositories for AIRR-seq data based on the FAIR principles.
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