期刊
MATTER
卷 3, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.matt.2020.09.027
关键词
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资金
- Merkin Institute for Translational Research at Caltech
- Tobacco-Related Disease Research Program (TRDRP)
- TRDRP High Impact Pilot Research Award
- National Institutes of Health [5R21NR018271]
- Translational Research Institute through NASA [NNX16AO69A]
- National Science Scholarship from the Agency for Science, Technology and Research (A*STAR), Singapore
The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical in preventing widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19-positive and COVID-19-negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high-frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.
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