期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 48, 期 10, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060520965824
关键词
Stem cell therapy; inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; bibliometric analysis; animal experiment; immunocyte; intestinal epithelial cell; cytokine expression; clinical efficacy
Background Inflammatory bowel disease (IBD) represents a series of digestive system abnormalities and parenteral manifestations. Stem cell therapy has been regarded as a promising treatment for IBD. Methods We searched Web of Science Core Collection for publications of interest from 1991 to 2019. Publication performance was analyzed using several bibliometric parameters, including Statplanet to reveal the geographic distribution of the publications, VOSviewer to identify the research landscape of hot topics, and CiteSpace to show keywords with the strongest citation bursts. Results A total of 1230 publications were identified, of which 674 articles were analyzed further. The United States was the most productive country and Spanish researchers published the highest quality articles. At a journal level, Gastroenterology published the greatest number of articles, while articles from Gut had the highest citation number. Results from the research landscape analysis of hot topics and the top 20 terms with the strongest citation bursts indicated that animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy were the main focuses of research. Conclusion Stem cell therapy for IBD is currently receiving increasing attention by researchers, with focuses on animal experiments, immunocytes, intestinal epithelial cells, cytokine expression, and clinical efficacy.
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