期刊
出版社
ELSEVIER
DOI: 10.1016/j.jchromb.2020.122343
关键词
Aristolochic acids; Solid-phase extraction; Metal organic frameworks; Medicinal plants; Enrichment and determination
资金
- National Natural Science Foundation of China [21974034, 21575033, 21505030]
- Natural Science Interdisciplinary Research Program of Hebei University [DXK201912]
In this study, modified UiO-66-NH2 and N-methylolacrylamide (NMA) were used as common monomers to prepare a metal organic framework (MOF)-based composite monolith through in-situ polymerization, which was used as a new adsorbent to purify and enrich aristolochic acid-I (AA-I) in medicinal plants. The MOF-based composite monolithic column was characterized by nitrogen adsorption-desorption isotherm, mercury intrusion porosimetry and scanning electron microscopy (SEM). The adsorption ability of MOF-based composite monolith for AA-I was compared with that of the polymer monolith without MOF added. The results proved that the addition of UiO-66-NH2 can increase both the specific surface area and the permeability of the monolith. Moreover, the adsorption amount of AA-I on the monolith improved. This proposed on-line solid phase ex-traction (SPE) method showed good linear relationship in the range 0.044 similar to 400 mu g/mL with r = 0.9994; the limit of detection (LOD) was 13.08 ng/mL and the limit of quantification (LOQ) was 44.00 ng/mL; the intra-day and inter-day accuracies were less than 0.97%; the inter-column accuracies was less than 6.11%; the recovery was in the range of 91.11%similar to 106.48%. The method was found to be easy, accurate and convenient for on-line enrichment and purification of AA-I in medicinal plants.
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