期刊
NATURAL PRODUCT REPORTS
卷 37, 期 11, 页码 1404-1435出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0np00003e
关键词
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资金
- National Institutes of Health (USA)
- Cancer Prevention & Research Institute of Texas (CPRIT)
- Robert A. Welch Foundation [C-1819]
- Bristol-Myers Squibb
- AbbVie Stemcentrx
By definition total synthesis is the art and science of making the molecules of living Nature in the laboratory, and by extension, their analogues. Although obvious, its application to the synthesis of molecules for biology and medicine was not always the purpose of total synthesis. In recent years, however, the field has acquired momentum as its power to reach higher molecular complexity and diversity is increasing, and as the demand for rare bioactive natural products and their analogues is expanding due to their recognised potential to facilitate biology and drug discovery and development. Today this component of total synthesis endeavors is considered highly desirable, and could be part of interdisciplinary academic and/or industrial partnerships, providing further inspiration and momentum to the field. In this review we provide a brief historical background of the emergence of the field of total synthesis as it relates to making molecules for biology and medicine. We then discuss specific examples of this practice from our laboratories as they developed over the years. The review ends with a conclusion and future perspectives for natural products chemistry and its applications to biology and medicine and other added-value contributions to science and society.
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