期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2020.577244
关键词
Klebsiella pneumoniae; intensive care unit (ICU); Carbapenem resistant Acinetobacter baumannii (CRAB); anti-bacterial agents— therapeutic use; bloodstream infection (BSI)
资金
- Overseas Research and Training Project of Talents of Health and Health Science and Technology in Henan Province in 2019 [HWYX2019020]
- Scientific and Technological Innovation Leaders in Central Plains [194200510017]
- Provincial Ministry CoConstruction Project from the Medical Scientific and Technological Research Program of Henan Province [SBGJ2018020]
- 51282 Project Leaders of Scientific and Technological Innovative Talents from Health and Family Planning Commission in Henan Province [2016-32]
- Key scientific research project plan of colleges and universities in Henan Province [18B310039]
- Science and Technology People-Benefit Project of Zheng Zhou [2019KJHM0001]
Background and purpose The clinical prognosis of Klebsiella pneumoniae(K. pneumoniae) bloodstream infection is poor, and the prevalence of drug-resistant bacteria makes clinical anti-infective treatment more challenging. This retrospective study evaluated the epidemiological characteristics of patients with K. pneumoniae, the risk factors for drug-resistant bacterial infection and death, and analyzed treatment options. Methods Clinical data of 297 patients diagnosed with K. pneumoniae bacteremia between June 2014 and June 2019 were collected. Results Intensive care unit hospitalization history, operation history, recent antibiotic use history, mechanical ventilation, and number of days hospitalized before bloodstream infection were found to be independent risk factors for drug-resistant bacterial infection. The risk of death for carbapenem-resistant K. pneumoniae infection was 2.942 times higher than that for carbapenem-sensitive K. pneumoniae infection. For extensively drug-resistant K. pneumoniae bacteremia patients, the mortality rate of combined anti-infective therapy was lower. Conclusions Clinicians should pay attention to patients with high-risk drug-resistant bacteria infection and administer timely anti-infection treatment. The findings of this study may provide some suggestions for early identification and standardized treatment of patients with K. pneumoniae bacteremia.
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