期刊
FUTURE MICROBIOLOGY
卷 15, 期 16, 页码 1571-1582出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2020-0118
关键词
COVID-19; drug toxicity; nanostructured delivery systems; nanotechnology
类别
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES- Brazil [88887.336865/2019-00]
There is no effective therapy against COVID-19 available so far. In the last months, different drugs have been tested as potential treatments for COVID-19, exhibiting high toxicity and low efficacy. Therefore, nanotechnology can be applied to improve the therapeutic action and minimize the toxicity of loaded drugs. In this review, we summarized the drugs tested as COVID-19 treatment and the advantages of antiviral nanostructured drug-delivery systems. Such systems have demonstrated low in vitro toxicity with better in vitro antiviral activity than free drugs. We believe that this approach should inspire novel nanostructured drug-delivery systems developments to find efficient COVID-19 treatments. Here, we discuss the remaining challenges for such promising nanosystems to be approved for clinical use.
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