A novel electrochemiluminescence sensor based on resonance energy transfer from MoS2QDs@g-C3N4 to NH2-SiO2@PTCA for glutathione assay

In this work, a solid-state electrochemiluminescence (ECL) sensor based on resonance energy transfer (RET) was proposed using MoS(2)QDs@g-C3N4 as a donor and NH2-SiO2@PTCA as an acceptor. Herein, MoS(2)QDs could significantly facilitate the stability and efficiency of the ECL of g-C3N4. PTCA provided a large platform to anchor NH2-SiO2 nanoparticles. The prepared MoS(2)QDs@g-C3N4 exhibited good spectral overlap with the UV-vis absorption spectrum of NH2-SiO2@PTCA. Based on this, we designed an off-on ECL sensing strategy for sensitive and selective detection of glutathione (GSH). Under the best conditions, the linear range of the sensor for GSH detection was from 0.001 to 100 mu M with a detection limit of 0.63 nM (S/N = 3). More importantly, GSH in commercial samples can be detected using the proposed sensor, which indicated its superior detection capabilities and potential application value in commercial medicines.