期刊
SCIENCE ADVANCES
卷 6, 期 47, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abc3916
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资金
- Italian Ministry of Health (Ricerca corrente, IRCCS Fondazione Santa 486 Lucia)
- Italian Space Agency [I/006/06/0, ASI-MARS-PRE DC-VUM 2017-006]
- Italian University Ministry (PRIN) [2017CBF8NJ_005]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [810346]
Motoneurons of neonatal rodents show synchronous activity that modulates the development of the neuromuscular system. However, the characteristics of the activity of human neonatal motoneurons are largely unknown. Using a noninvasive neural interface, we identified the discharge timings of individual spinal motoneurons in human newborns. We found highly synchronized activities of motoneurons of the tibialis anterior muscle, which were associated with fast leg movements. Although neonates' motor units exhibited discharge rates similar to those of adults, their synchronization was significantly greater than in adults. Moreover, neonatal motor units showed coherent oscillations in the delta band, which is directly translated into force generation. These results suggest that motoneuron synchronization in human neonates might be an important mechanism for controlling fast limb movements, such as those of primitive reflexes. In addition to help revealing mechanisms of development, the proposed neural interface might monitor children at risk of developing motor disorders.
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