Magneto-structural and induction heating properties of MFe2O4 (M = Co, Mn, Zn) MNPs for magnetic particle hyperthermia application

The complex decomposition approach was used for the synthesis of MFe2O4 magnetic nanoparticles (MNPs) by substituting M as Co, Mn, and Zn. The obtained MNPs were characterized for magneto-structural properties using X-Ray diffraction patterns, FTIR, Raman and Mossbauer spectroscopy techniques which validate the synthesis of phase pure cubic spinel ferrite (space group Fd3m) with five Raman active modes. Magnetic properties confirmed using Mossbauer spectroscopy. The size, morphology, and compositional analysis was performed using HRTEM and EDX where the size of MNPs was found to be less than 10 nm that attains superparamagnetism with 39.0, 58.28, and 44.24 emu gm(-1) moment for CoFe2O4, MnFe2O4, and ZnFe2O4, respectively. The magnetic hyperthermia performance of obtained MNPs was evaluated by induction heating experiments at magnetic field range 13.3-26.7 kAm(-1). The specific absorption rate (SAR) and intrinsic loss power (ILP) values were determined at different magnetic fields and mutually related with magneto-structural properties to evaluate its potential for magnetic particle hyperthermia therapy. The CoFe2O4 MNP exhibits a maximum temperature rise of 25 and 35 degrees C for 5 and 10 mgmL(-1) concentrations with threshold temperature rise.