期刊
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2020.602617
关键词
developmental hematopoiesis; hematopoietic stem cell; hemogenic endothelium; endothelial cell; vascular niches; aorta gonad mesonephros region; yolk sac; fetal liver
资金
- National Heart, Lung, and Blood Institute of the NIH [K08HL140143]
- American Society of Hematology Scholar Award
- Takeda Science Foundation
- Nakatomi Foundation
- Kitasato University School of Medicine Alumni Association
During embryonic development, sequential waves of hematopoiesis give rise to blood-forming cells with diverse lineage potentials and self-renewal properties. This process must accomplish two important yet divergent goals: the rapid generation of differentiated blood cells to meet the needs of the developing embryo and the production of a reservoir of hematopoietic stem cells to provide for life-long hematopoiesis in the adult. Vascular beds in distinct anatomical sites of extraembryonic tissues and the embryo proper provide the necessary conditions to support these divergent objectives, suggesting a critical role for specialized vascular niche cells in regulating disparate blood cell fates during development. In this review, we will examine the current understanding of how organ- and stage-specific vascular niche specialization contributes to the development of the hematopoietic system.
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