期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 87, 页码 13327-13330出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc05315e
关键词
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资金
- JSPS KAKENHI [JP19K23816, JP19K07035]
- Zero Emission Research Program, Institute of Advanced Energy, Kyoto Univ. [ZE2020C-06]
- Vehicle Racing Commemorative Foundation [6110]
Labile zinc plays various roles in cells at low concentrations which most fluorescent probes are not able to detect. Here we report a cephem-based probe which coordinates to zinc and zinc-bound water cleaves the scaffold and releases the fluorophore. In addition, the zinc is recycled and reacts with multiple probes, amplifying the signal. This signal amplification system is useful for the detection of intracellular zinc at low concentrations and has potential for further development of probes with a similar molecular design.
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