Dual-readout proximity hybridization-regulated and photothermally amplified protein analysis based on MXene nanosheets

Herein, an ingenious dual-readout sensing platform based on a proximity hybridization-regulated strategy is proposed for protein detection. For the first time, Ti3C2 MXene@thionine composites (MXene@Thi) with an excellent photothermal effect not only acted as an amplifier to enhance the electrochemical signal, but were also used as a converter to achieve the temperature readout.