期刊
MATERIALS
卷 13, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ma13215010
关键词
antiproliferative activity; azanorbornane derivatives; bicyclic compounds; sulfonamide
类别
资金
- ILTSR PAS
In a search for new, selective antitumor agents, we prepared a series of sulfonamides built on bicyclic scaffolds of 2-azabicyclo(2.2.1)heptane and 2-azabicyclo(3.2.1)octane. To this end, aza-Diels-Alder cycloadducts were converted into amines bearing 2-azanorbornane or a bridged azepane skeleton; their treatment with sulfonyl chlorides containing biaryl moieties led to the title compounds. The study of antiproliferative activity of the new agents showed that some of them inhibited the growth of chosen cell lines with the IC50 values comparable with cisplatin, and some derivatives were found considerably less toxic for nonmalignant cells.
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