期刊
JOURNAL OF TISSUE ENGINEERING
卷 11, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731420965318
关键词
Microfluidics; gut-on-chip; host-microbiome interactions; drug pharmacokinetics; artificial gut
资金
- National Key Research and Development Program of China [2018YFA0903400]
- National Natural Science Foundation of China [31770111, 31971350, 31800083]
- Shenzhen Science Technology and Innovation Commission [JCYJ20170413153329565, JCYJ20170818160418654, JCYJ20180302145817753, KQTD20 16112915000294]
- CAS Interdisciplinary Innovation Team [JCTD-2019-16]
- Instrumental Project from Chinese Academy of Science [YJKYYQ20170063]
- China Postdoctoral Science Foundation [2017M622832, 2018M631002]
- Shenzhen Biofoundry
The human gut is important for food digestion and absorption, as well as a venue for a large number of microorganisms that coexist with the host. Although numerous in vitro models have been proposed to study intestinal pathology or interactions between intestinal microbes and host, they are far from recapitulating the real intestinal microenvironment in vivo. To assist researchers in further understanding gut physiology, the intestinal microbiome, and disease processes, a novel technology primarily based on microfluidics and cell biology, called gut-on-chip, was developed to simulate the structure, function, and microenvironment of the human gut. In this review, we first introduce various types of gut-on-chip systems, then highlight their applications in drug pharmacokinetics, host-gut microbiota crosstalk, and nutrition metabolism. Finally, we discuss challenges in this field and prospects for better understanding interactions between intestinal flora and human hosts, and then provide guidance for clinical treatment of related diseases.
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