期刊
MATTER
卷 3, 期 5, 页码 1725-1753出版社
CELL PRESS
DOI: 10.1016/j.matt.2020.08.027
关键词
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资金
- Natural Science Foundation of China [21877049]
- Major Program for Tackling Key Problems of Industrial Technology in Guangzhou [201902020013]
- Dedicated Fund for Promoting High-Quality Marine Economic Development in Guangdong Province [GDOE-2019-A31, 2020-035]
- Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation [201905010003]
- US METAvivor Early Career Investigator award [2018A020560]
- Innovation Team Project in Guangdong Colleges and Universities [2019KCXTD008]
- K.C. Wong Education Foundation
- Guangdong Provincial Key Laboratory Fund of Functional Supramolecular Coordination Materials
- Harvard Medical School/Brigham and Women's Hospital Department of Anesthesiology-Basic Scientist grant [2420 BPA075]
Checkpoint blocking-based immunotherapy has been proved to be effective for the treatment of cancer, but its dependence on T cell infiltration has limited its effectiveness across patients. Radio-therapy (RT) is becoming the most common method of clinical tumor treatment but can occasionally cause systemic tumor rejection. Here, we demonstrate a simple one-pot hydrothermal method to synthesize tellurium (Te) nanostars (GTe-RGD) and offer a treatment strategy that combines GTe-RGD-potentiated RT with checkpoint blockade immunotherapy for efficient and systemic tumor elimination. In mouse models of breast cancer, GTe-RGD-potentiated RT not only eradicated primary tumors but also elicited antitumor immunity to inhibit growth at distant sites by enhancing cytotoxic T lymphocytes when combined with an immune checkpoint inhibitor. Furthermore, the triggered release of tumor-associated antigens and cytokines can effectively reduce the percentage of M2 macrophages with enhanced antitumor activity. Thus, this simply synthe-sized Te-based nanomedicine, with radiation-driven immunotherapy, offers an attractive clinical alternative for tumor treatment.
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