期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms21228483
关键词
cytochrome c; mitochondrial diseases; post-translational modifications
资金
- Ministry of Science and Innovation [PGC2018-096049-B-I00]
- European Regional Development Fund [FEDER]
- Andalusian Government [BIO-198, US-1254317, US-1257019, P18-FR-3487]
- VI PPIT-US
- TA Instruments
- Spanish Ministry of Education, Culture and Sport [FPU17/04604]
Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including neurodegenerative diseases, cardiovascular diseases, and various types of cancer. In mitochondrial metabolism, cytochrome c is a small soluble heme protein that acts as an essential redox carrier in the respiratory electron transport chain. However, cytochrome c is likewise an essential protein in the cytoplasm acting as an activator of programmed cell death. Such a dual role of cytochrome c in cell life and death is indeed fine-regulated by a wide variety of protein post-translational modifications. In this work, we show how these modifications can alter cytochrome c structure and functionality, thus emerging as a control mechanism of cell metabolism but also as a key element in development and prevention of pathologies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据