期刊
NUTRIENTS
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/nu12113431
关键词
biomarker; urine; polyphenols; fruit; vegetables
资金
- Hunter Medical Research Institute [13-54]
- Australian Government Research Training Program (RTP) Scholarship
- NHMRC Senior Research Fellowship
- University of Newcastle, Faculty of Health and Medicine
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/R012512/1, BBS/E/F/000PR10343, BBS/E/F/000PR10346, BB/CCG1860/1]
- BBSRC [BBS/E/F/000PR10346, BBS/E/F/00044434, BBS/E/F/000PR10343] Funding Source: UKRI
Urinary polyphenol metabolites are potential biomarkers of dietary polyphenol intake. The current study aims to evaluate associations between total diet, vegetable and fruit polyphenol intakes with urinary polyphenol metabolite concentrations in a sample of adults prescribed a diet rich in vegetables and fruit. Thirty-four participants completed a 10-week pre-post study. Participants were asked to consume Australian recommended daily vegetable and fruit serves and attend measurement sessions at baseline and at weeks 2 and 10. Two 24-h diet recalls were collected at each time-point and polyphenol intakes were calculated using the Phenol-Explorer database. Spot urine samples, collected at each time-point, were analyzed for 15 polyphenol metabolites using liquid chromatography-mass spectroscopy. Spearman's correlation analyzes assessed the strength of relationships between urinary and dietary polyphenols. Linear mixed models were used to investigate relationships between polyphenol excretion and intake. Total urinary polyphenols were significantly correlated with total polyphenol intakes at week 10 (r(s) = 0.47) and fruit polyphenols at week 2 (r(s) = 0.38). Hippuric acid was significantly correlated with vegetable polyphenols at baseline (r(s) = 0.39). Relationships were identified between individual polyphenol metabolites and vegetable and fruit polyphenols. Linear mixed model analyzes identified that for every 1 mg increase in polyphenol intakes, urinary polyphenol excretion increased by 16.3 nmol/g creatinine. Although the majority of relationships were not sufficiently strong or consistent at different time-points, promising relationships were observed between total urinary polyphenols and total polyphenol intakes, and hippuric acid and vegetable polyphenols.
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