期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 163, 期 -, 页码 36-43出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.06.165
关键词
Water soluble chitosan; Trigonelline; Nanoparticles; TEM; Glioblastoma; Biocompatibility
资金
- University Grants Commission-Basic Scientific Research fellowship, New Delhi, India [25-1/2014-15 (BSR)/5-61/2007]
- scheme of UGC-BSR
Trigonelline-loaded water-soluble chitosan nanoparticles (Trigo-WSCS NPs) were prepared for the treatment of glioblastoma (targeting C6 glioma cells) and also evaluated its biocompatibility with rat adrenal pheochromocytoma cells (PC12 cells). WSCS-Trigo NPs characteristics were determined using UV-Visible spectrophotometer, FTIR, XRD, TEM, DLS, and Zeta potential. Trigo-WSCS NPs were noted to have a spherical shape, with an average size of 356 nm. Trigo-WSCS NPs zeta potential was 30.9 mv, which expresses its good stability. The WSCS-Trigo NPs considerably inhibited the growth of rat C6 glioma cells and exhibited an IC50 concentration of 34 mu g/mL. Further, Trigo-WSCS NPs were biocompatible with PC12 cells in terms of enhancing neurite growth and differentiation. In conclusion, Trigo-WSCS NPs could act as an antitumor drug for the treatment of glioblastoma as suggested by the in vitro studies. (C) 2020 Elsevier B.V. All rights reserved.
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