期刊
DALTON TRANSACTIONS
卷 49, 期 45, 页码 16004-16033出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0dt02478c
关键词
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资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) - Brasil - Prevention and Combat of Outbreaks, Endemics, Epidemics and Pandemics [88881.506794/2020-01]
- Royal Society - Newton Advanced Fellowship [NA 150195]
- FAPEMIG (Minas Gerais Research Foundation) [APQ-00587-14, SICONV 793988/2013, APQ-03385-18]
- Sao Paulo Research Foundation (FAPESP) [2018/21537-6]
- FAPESP [2018/12062-4]
- CAPES [001]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/12062-4] Funding Source: FAPESP
In light of the Covid-19 outbreak, this review brings together historical and current literature efforts towards the development of antiviral metallodrugs. Classical compounds such as CTC-96 and auranofin are discussed in depth, as pillars for future metallodrug development. From the recent literature, both cell-based results and biophysical assays against potential viral biomolecule targets are summarized here. The comprehension of the biomolecular targets and their interactions with coordination compounds are emphasized as fundamental strategies that will foment further development of metal-based antivirals. We also discuss other possible and unexplored methods for unveiling metallodrug interactions with biomolecules related to viral replication and highlight the specific challenges involved in the development of antiviral metallodrugs.
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