期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 21, 期 21, 页码 -出版社
MDPI
DOI: 10.3390/ijms21218031
关键词
cardiolipin; cancer; mitochondria
资金
- Ligue Nationale Contre le Cancer
- Canceropole Grand Ouest (CONCERTO)
- (Pays de Loire et Bretagne)
- Fondation ARC pour la recherche sur le cancer
Cardiolipins (CLs) are specific phospholipids of the mitochondria composing about 20% of the inner mitochondria membrane (IMM) phospholipid mass. Dysregulation of CL metabolism has been observed in several types of cancer. In most cases, the evidence for a role for CL in cancer is merely correlative, suggestive, ambiguous, and cancer-type dependent. In addition, CLs could play a pivotal role in several mitochondrial functions/parameters such as bioenergetics, dynamics, mitophagy, and apoptosis, which are involved in key steps of cancer aggressiveness (i.e., migration/invasion and resistance to treatment). Therefore, this review focuses on studies suggesting that changes in CL content and/or composition, as well as CL metabolism enzyme levels, may be linked with the progression and the aggressiveness of some types of cancer. Finally, we also introduce the main mitochondrial function in which CL could play a pivotal role with a special focus on its implication in cancer development and therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据