期刊
ACS MACRO LETTERS
卷 9, 期 11, 页码 1687-1692出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.0c00759
关键词
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资金
- Deakin University
- CSIRO
- Natural Sciences and Engineering Council of Canada
Hypoxia-activated prodrugs (HAPs) have emerged as important candidates for chemotherapy due to their efficient killing of hypoxic cancer cells. Traditional small molecule agents, such as tirapazamine (TPZ) and its derivatives, have shown unsatisfactory therapeutic effect in clinical trials due to poor bioavailability in hypoxic tumor regions. Herein, an amphiphilic macromolecular prodrug with hypoxia-specific activity, named as hypoxia-activated macromolecular prodrug (HAMP), is prepared from poly{[poly(ethylene glycol) methacrylate]-st-(methacrylic acid)} [poly(PEGMA-st-MAA)], containing pendant TPZ residues. This polymer can self-assemble in an aqueous system into similar to 37 nm sized nanoparticles. In vitro experiments indicated that HAMP shows 5x higher cytotoxicity to hypoxic cancer cells as compared to normoxic cancer cells. Therefore, the developed HAMP can be concurrently used with other therapeutic agents as a highly efficient hypoxia-activated agent.
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