期刊
NANOSCALE
卷 12, 期 46, 页码 23824-23830出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr04102e
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资金
- AXA Chair (2016-2023)
- MINECO [IJCI-2016-31113, IJC-2018-037396, BES-2017-081563]
- Graphene Flagship Core 2 [785219]
- Graphene Flagship Core 3 [881603]
- EU H2020-MSCA-RISE-2016 [734381]
- Spanish State Research Agency [MDM-2017-0720]
Graphene-based materials are particularly suitable platforms for the development of new systems able to release drugs upon the application of controlled electrochemical stimuli. Herein, we report a new electro-responsive graphene carrier functionalised with aldehydes (as drug models) through imine-based linkers. We explore a new type of drug loading/release combination based on the formation of a covalent bond and its cleavage upon electrolysis. The new graphene-drug model hybrid is stable under physiological conditions and displays a fast drug release upon the application of low voltages.
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