期刊
FOOD RESEARCH INTERNATIONAL
卷 137, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2020.109437
关键词
Circadian rhythm; Chrononutrition; Diurnal rhythmicity; Nutrigenetics; Rhythmicity analysis; Polysaccharide; Shift work
资金
- United College Endowment Fund [CA11282]
- Chinese University of Hong Kong
Circadian rhythm governs multiple behavioural and physiological processes and its disruption is closely associated with various pathological conditions. In this study, the effects of dietary intervention by prebiotics including beta-glucan and inulin on attenuating circadian desynchrony in C57BL/6J mice subjected to weekly shifted light-dark cycle under a high fat diet was investigated. Using RT-qPCR and rhythmicity analysis, our study revealed that beta-glucan (0.2 g/day) and inulin (0.2 g/day) modulated the expression and phase of circadian-clock genes, explicitly reversed the phase delay of Period 1 and Period 3 in the hypothalamus, and reversed the phase delay of Period 2 in the liver of the mice. In the shifted mouse group, inulin also exhibited its reversal effects on the phase advance of Brain and muscle-Arnt-like 1 in the hypothalamus. These findings indicated that prebiotic supplementation can be a novel dietary approach for attenuating circadian misalignment.
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